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Literature summary extracted from

  • Beintema, J.J.; Campagne, R.N.; Gruber, M.
    Rat pancreatic ribonuclease. I. Isolation and properties (1973), Biochim. Biophys. Acta, 310, 148-160.
    View publication on PubMed

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
4.6.1.18 2.4 3.5 2',3'-cyclic UMP pancreas Bos taurus
4.6.1.18 3
-
 cyclic 2',3'-UMP
-
 Rattus norvegicus
4.6.1.18 5.1 5.9 cyclic 2',3'-CMP
-
 Rattus norvegicus
4.6.1.18 5.2 7.5 cyclic 2 ',3'-CMP
-
 Rattus norvegicus

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
4.6.1.18 15000
-
 pancreas, ultracentrifugation Rattus norvegicus
4.6.1.18 15000
-
 pancreas, ultracentrifugation Bos taurus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
4.6.1.18 RNA + H2O Rattus norvegicus endonucleolytic cleavage to 3'-phosphomononucleotides and 3'-phosphooligonucleotides ending in Cp or Up with 2',3'-cyclic phosphate intermediates, e.g. tRNA, 18S and 28S rRNA, yeast RNA,4.5S RNA 3'-phosphomononucleotides + 3'-phosphooligonucleotides
-
 ?
4.6.1.18 RNA + H2O Bos taurus endonucleolytic cleavage to 3'-phosphomononucleotides and 3'-phosphooligonucleotides ending in Cp or Up with 2',3'-cyclic phosphate intermediates, e.g. tRNA, 18S and 28S rRNA, yeast RNA,4.5S RNA 3'-phosphomononucleotides + 3'-phosphooligonucleotides
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
4.6.1.18 Bos taurus
-
-
-
4.6.1.18 Rattus norvegicus
-
-
-

Posttranslational Modification

EC Number Posttranslational Modification Comment Organism
4.6.1.18 glycoprotein
-
 Rattus norvegicus
4.6.1.18 glycoprotein
-
 Bos taurus

Purification (Commentary)

EC Number Purification (Comment) Organism
4.6.1.18
-
 Rattus norvegicus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
4.6.1.18 pancreas
-
 Rattus norvegicus
-
4.6.1.18 pancreas
-
 Bos taurus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4.6.1.18 2',3'-cyclic UMP + H2O
-
 Bos taurus uridine 3'-phosphate
-
 ?
4.6.1.18 cyclic 2',3'-cytidine monophosphate + H2O
-
 Rattus norvegicus 3'-CMP
-
 ir
4.6.1.18 cyclic 2',3'-cytidine monophosphate + H2O
-
 Bos taurus 3'-CMP
-
 ir
4.6.1.18 cyclic 2',3'-nucleoside monophosphate + H2O second step of hydrolysis is irreversible Rattus norvegicus 3'-phosphomononucleotides
-
 ir
4.6.1.18 cyclic 2',3'-nucleoside monophosphate + H2O second step of hydrolysis is irreversible Bos taurus 3'-phosphomononucleotides
-
 ir
4.6.1.18 cyclic 2',3'-uridine monophosphate + H2O
-
 Rattus norvegicus 3'-UMP
-
 ir
4.6.1.18 RNA + H2O endonucleolytic cleavage to 3'-phosphomononucleotides and 3'-phosphooligonucleotides ending in Cp or Up with 2',3'-cyclic phosphate intermediates, e.g. tRNA, 18S and 28S rRNA, yeast RNA,4.5S RNA Rattus norvegicus 3'-phosphomononucleotides + 3'-phosphooligonucleotides
-
 ?
4.6.1.18 RNA + H2O endonucleolytic cleavage to 3'-phosphomononucleotides and 3'-phosphooligonucleotides ending in Cp or Up with 2',3'-cyclic phosphate intermediates, e.g. tRNA, 18S and 28S rRNA, yeast RNA,4.5S RNA Bos taurus 3'-phosphomononucleotides + 3'-phosphooligonucleotides
-
 ?
4.6.1.18 RNA + H2O first step of hydrolysis is reversible Rattus norvegicus cyclic 2',3'-nucleoside monophosphate
-
 r
4.6.1.18 RNA + H2O first step of hydrolysis is reversible Bos taurus cyclic 2',3'-nucleoside monophosphate
-
 r

Turnover Number [1/s]

EC Number Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
4.6.1.18 0.6 1.1 cyclic 2',3'-UMP
-
 Rattus norvegicus
4.6.1.18 1.5 2.2 cyclic 2',3'-CMP
-
 Rattus norvegicus
4.6.1.18 1.6 2.5 cyclic 2',3'-CMP
-
 Rattus norvegicus
4.6.1.18 2.7 3.7 cyclic 2',3'-UMP
-
 Rattus norvegicus